Bones and teeth have a very similar chemical composition. Enamel consists of 96% inorganic substances and 4% organic substances and water; dentin consists of 65% inorganic substances and 35% organic substances and water; cementum consists of 45–50% inorganic substances and 50–55% organic substances and water; and alveolar bone consists of 65% inorganic substances and 35% organic substances and water. Thus, the teeth are known to be an organic-inorganic hybrid composed of calcium phosphates with collagen and other organic compounds. Furthermore, dentin consists of hydroxyapatite (HA), type I collagen, and matrix proteins, such as bone morphogenetic protein (BMP), dentin sialophosphoprotein, and dentin matrix protein-1. Therefore, the application of dentin-derived matrix in bone grafting can be effective in promoting bone formation. The clinical applications of autogenous demineralized dentin matrix (DDM) have been standardized in Korea. Long-term clinical studies have reported the development of several types of DDM, such as powders, blocks, moldable forms, and composites, with recombinant human bone morphogenetic protein-2. In this presentation, I would like to elucidate the rationale for clinical application of DDM, and to introduce the application for several types of DDM with various implant cases.